Sikeston, MO to Effingham, IL

EXIT #

NORTH

SOUTH

 

 

Continue on US 60 (fictional I-66) to Springfield

1 A-B

St. Louis

Memphis

MILE 1.9

Mississippi County

Scott County

8

Bertrand

10

Charleston

East Prairie

12

Charleston

Wyatt

MILE 21.9 (0.0)

ILLINOIS STATE LINE

Alexander County

MISSOURI STATE LINE

Mississippi County

1

 SOUTH

Cairo

8

Mounds Rd

18

Ullin Rd

MILE 22

Union County

Alexander County

24

Dongola Rd

25

NORTH

Anna

30

Anna

Vienna

MILE 32

REST AREA / TRAVEL INFORMATION CENTER

REST AREA

36

Lick Creek Rd

MILE 39

Johnson County

Union County

40

Goreville Rd

44

EAST

Nashville

MILE 44

Williamson County

Johnson County

45

Pulleys Mill

Herrin

53

W Main St

54 A-B

Marion

Carbondale

59

Johnston City

MILE 63

Franklin County

Williamson County

65

W Frankfort

Ziegler

71

Benton

Christopher

MILE 74

REST AREA

 

77

Sesser

Rend Lake

MILE 79

 

REST AREA

MILE 80

Jefferson County

Franklin County

83

North Ave

Ina

92

EAST

Louisville

95

Mt. Vernon

Ashley

96

WEST

St. Louis

103

Texico Rd

MILE 106

Marion County

Jefferson County

109

Centralia

MILE 114

REST AREA

REST AREA

116

Salem

Odin

127

Kinoka Rd

MILE 134

Fayette County

Marion County

135

Farina

Vandalia

MILE 143

Effingham County

Fayette County

145

Edgewood

151

TO

Mason

Watson

157

WEST

St. Louis

159

Fayette Ave

160

 

162

Effingham

Sigel

163

EAST

Indianapolis

 

Continue north to Chicago

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