St. Louis to Indiana State Line

I-64 is multiplexed with I-55 and I-70 from the Mississippi River to I-55/70 exit 2 (eastbound). Exit list below reflects the multiplex west of I-64 exit 3.

EXIT #

EAST

WEST

 

 

Continue west to Wentzville

1

 SOUTH

Cahokia

E St Louis

2 A

 

3rd Street

Eads Bridge

2 B

 

ML King Bridge

Downtown St Louis

2 C

 

ML King Bridge

Downtown St Louis

3

 

NORTHEAST

Chicago

Indianapolis

4

15th Street

Baugh Ave

5

25th Street

6

Kingshighway

7 A-B

Chicago

Memphis

9

Caseyville

Centreville

12

Collinsville

Belleville

14

O'Fallon

16

O'Fallon

Shiloh

19 A-B

EAST 

O'Fallon

Scott AF Base

23

Lebanon

Mascoutah

MILE 25

REST AREA / TRAVEL INFORMATION CENTER

REST AREA

27

New Baden

MILE 30

Clinton County

St. Clair County

34

Albers

MILE 36

Washington County

Clinton County

41

Okawville

50

Nashville IL

Carlyle

61

Centralia

Ashley

MILE 63

Jefferson County

Washington County

69

Woodlawn

73

NORTH

Chicago

 

(95)

Mt. Vernon

Ashley

78

 

SOUTH

Memphis

80

Mt Vernon

MILE 85

REST AREA

REST AREA

89

Belle Rive

Bluford

MILE 91

Wayne County

Jefferson County

100

Wayne City

Mc Leansboro

110

Fairfield

Norris City

MILE 116

White County

Wayne County

117

Burnt Prairie

130

Grayville

Carmi

MILE 131

 

REST AREA

MILE 132

INDIANA State Line

ILLINOIS State Line

 

Continue east in Indiana

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